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ねがてぃぶふぃーどばっく
(n)
negative feedback
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用例
Activation of PKA may constitute a negative-feedback mechanisms for lowering cAMP levels.
(Proc Natl Acad Sci USA)
It is expected that their activation would provide negative feedback to transmitter release, but the opposite is sometimes observed.
(J Neurosci)
Voltage-gated Ca2+ channels undergo a negative feedback regulation by Ca2+ ions, Ca2+-dependent inactivation, which is important for restricting Ca2+ signals in nerve and muscle.
(J Biol Chem)
An increase in circulating glucose inhibits glucose production in the liver, but this negative feedback is impaired in type 2 diabetes.
(Science)
Positive and negative feedback loops, for example, where a protein regulates its own transcription, play an important role in many genetic regulatory networks.
(J Theor Biol)
In all genetically studied model organisms, a negative feedback loop of gene expression contributes to the circadian rhythm mechanism.
(Mol Cell)
Loss of hepatic P450 activity resulted in a 5-fold increase in P450 protein, indicating the existence of a negative feedback pathway regulating P450 expression.
(J Biol Chem)
The catestatin fragment of chromogranin A is an endogenous inhibitor of nicotinic cholinergic transmission, functioning in negative feedback control of catecholamine secretion.
(Mol Pharmacol)
Such negative regulatory feedback loops between signalling molecules are likely to be critical for limb patterning in other species.
(Nature)
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