bile canaliculusとは 意味・読み方・使い方

The method includes the steps of: providing a culture of hepatocytes, the culture having at least one bile canaliculus; exposing a candidate compound to the culture; and determining an amount of candidate compound in the at least one bile canaliculus, the amount of candidate compound in the at least one bile canaliculus indicating the susceptibility of the candidate compound to biliary excretion.例文帳に追加

肝細胞の培養物であって、少なくとも１個の毛細胆管を有する培養物を提供すること；当該培養物に対し候補化合物をさらすこと；および少なくとも１個の毛細胆管中の候補化合物の量であって、候補化合物の胆汁排泄感受性を示す少なくとも１個の毛細胆管の候補化合物の量の測定することをステップに含む。 - 特許庁

The method includes the steps of: providing a culture of hepatocytes comprising a transport protein, the culture having at least one bile canaliculus; and determining an amount of candidate compound in the at least one bile canaliculus, the amount of candidate compound in the at least one bile canaliculus indicating the susceptibility of the candidate compound to biliary excretion by the transport protein.例文帳に追加

輸送タンパク質を含む肝実質細胞の培養物を提供する段階、該培養物は、少なくとも１つの毛細胆管を有し；かつ該少なくとも１つの毛細胆管内の候補化合物の量を決定する段階を含み、少なくとも１つの毛細胆管中の候補化合物の量は、輸送タンパク質による胆汁中排泄に対する、候補化合物の感受性を示す。 - 特許庁

Determining the amount of candidate compound in the bile canaliculus comprises inhibiting expression of the transport protein, and comparing amounts of compound in the canalicules with and without inhibition of the transport protein.例文帳に追加

毛細胆管中の候補化合物の量を決定することは、輸送タンパク質の発現を阻害すること、及び輸送タンパク質の阻害の有無で、小管中の化合物の量を比較することを含む。 - 特許庁