「PKA」の共起表現一覧(1語右で並び替え)

PKA

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  • lls, it has been shown that a protein kinase A ( PKA) activator will increase the quantity of NAAG,
  • Although PKA also phosphorylates hormone-sensitive lipase, w
  • Selenocysteine has both a lower pKa and a higher reduction potential than cysteine.
  • This finding suggests that PKA and PKC have opposing regulatory effects on the
  • bstrates to be regulated by phosphorylation (by PKA) and dephosphorylation (by phosphatases).
  • to bind both regulatory subunits (RI & RII) of PKA and are dual-specific AKAPs (D-AKAP1 and D-AKAP
  • cleus of a heart muscle cell would bind to both PKA and phosphodiesterase that hydrolyzes cAMP.
  • to the regulatory subunit of protein kinase A ( PKA) and confining the holoenzyme to discrete locat
  • ause dielectric constant has a strong effect on pKa, and the dielectric constant of air is quite lo
  • cAMP robustly increases Arc levels while H89, a PKA antagonist, blocks these effects as does furthe
  • PKA binds directly to an AKAP by its regulatory sub
  • This cleavage in turn activates PKA by exposing the catalytic sites of the C subuni
  • See Qin et al. for an example of a pKa calculation.
  • ater solution, with acid dissociation constant ( pKa) equal to 3.18.
  • With a pKa exceeding 15, the hydrosulfide ion cannot be de
  • In protein synthesis, PKA first directly activates CREB, which binds the
  • Perilipin is hyperphosphorylated by PKA following β-adrenergic receptor activation.
  • The pKa for binding of calcium ions by tetrabasic EGTA
  • PKA helps transfer/translate the dopamine signal in
  • Its pKa is −10.
  • The first pKa is 9.2.
  • Thus, PKA is controlled by cAMP.
  • The pKa is 6.8-7.20 (depending on the physicochemical c
  • ospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit S
  • ated compound, dimethyl malonate (whose aqueous pKa is around 13).
  • When phospholamban is phosphorylated by PKA its ability to inhibit the sarcoplasmic reticul
  • roximity to the scissile phosphate as well as a pKa lowered by its contact with the metal and its o
  • The catalytic subunit of PKA must bind four molecules of cAMP to be activate
  • The pKa of HEPPS is 8.00.
  • LiTMP has a pKa of 37.
  • Boric acid has a pKa of 9.14 at 25C.
  • It is moderately basic, with a pKa of 6.7.
  • Amine oxides are weak bases with a pKa of around 4.5 that form R3N+-OH, cationic hydro
  • Newer compounds have a pKa of around 5-6 so the problem is avoided.
  • pKa of phenolic compounds can be calculated from th
  • Meldrum's acid has a high acidity with a pKa of 4.97.
  • ion, 4-nitrophenol has a dissociation constant ( pKa) of 7.08 at 22 °C.
  • With a pKa of 3.47, 3-nitrobenzoic acid is about 10x more
  • With a pKa of 15, cyclopentadiene can be deprotonated by m
  • Iodic acid is a relatively strong acid with a pKa of 0.75.
  • It is one of Good's buffers and has a pKa of 8.35 at 20 °C.
  • Ammonium bromide is a weak acid with a pKa of ~5 in water.
  • It is a strong base with pKa of the conjugate acid of 11.0.
  • l carbonyl hydrides, HCo(CO)4 is acidic, with a pKa of 8.5.
  • proton in pyrroles is moderately acidic with a pKa of 16.5.
  • Methyl orange has a pKa of 3.47 in water at 25 degrees Celsius.
  • rong, non-nucleophilic base with an approximate pKa of 26 (compare to lithium diisopropylamide, at
  • dissociation of - 360 kJ/mol is equivalent to a pKa of - 63.
  • st acidic of the carbon acids with an estimated Pka of -5.
  • xazole is a weak base; its conjugate acid has a pKa of 0.8, compared to 7 for imidazole.
  • nic tertiary amine with labile protons having a pKa of 6.46 at 25°C.
  • It is a weak acid, bordering on strong, with a pKa of 1.1 at 20°C and extrapolated to zero ionic s
  • an crystallize in the kidneys, due to its first pKa of around 10.
  • The pKa of trinitromethane has been measured at 0.17 ±
  • As an acid, the pKa of imidazole is 14.5, making it less acidic tha
  • ce of buffer solution with a pH at or below the pKa of the surface silanol groups.
  • about 1000x stronger acids than are thiols: the pKa of CH3SeH is 5.2 vs 8.3 for CH3SH.
  • wo different pH conditions (above and below the pKa of the substance).
  • rotonation/deprotonation equilibrium exhibits a pKa of 4.88; consequently, about 0.3% of any supero
  • stable over a wide pH range, and with a primary pKa of 10.28, will only deprotonate at high pH, so
  • As a base, the pKa of the conjugate acid (cited above as pKBH+ to
  • The pKa of a compound is determined by many things, but
  • Therefore, one can easily find the pKa of the monoprotic acid by finding the pH of the
  • In addition, phosphorylation by MAPK, PKA, PKC or cdc2 alters the activity and stability
  • 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b).
  • Thus, activators of PKA, such as the beta-adrenergic agonist epinephrin
  • , phosphatases which dephosphorylate downstream PKA targets and also other kinases (PKC and MAPK).
  • lguanidine is a strong amine base with a higher pKa than typical amines, therefore it can be used w
  • These acids have higher pKa than strong acids, which release all of their h
  • Hydrogen tellurite loses a proton at this pKa to become the tellurite ion.
  • ent charges and dipoles) are added to the model pKa value to give the intrinsic pKa value.
  • A low pKa value indicates that the compound is acidic and
  • ts of the protein environment on the amino acid pKa value are divided into pH-independent effects a
  • molecule to give up a proton is measured by its pKa value.
  • nsively since the difference between successive pKa values is small.
  • Low-barrier hydrogen bonds and unusual pKa values for the catalytic residues have been pro
  • id being one of the strongest known acids (with pKa values cited in the range of -7 .. -10).
  • er are available for the calculation of protein pKa values.
  • cAMP will then activate cAMP dependent kinase ( PKA), which among other proteins that it acts on, i
  • A would sometimes couple with the AKAP, binding PKA with phosphodiesterase to form a complex that f