ロピナビル及びリトナビルと、少なくとも50℃のTgを有する医薬適合性の水溶性ポリマーと、4から10のHLB値を有する医薬適合性の界面活性剤と、を含む溶融物を固体化させることを含む、固体薬物剤形の製造方法。 There is provided a method of producing a solid pharmaceutical dosage form, including solidifying a melt which includes: lopinavir and ritonavir; a pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50°C; and a pharmaceutically acceptable surfactant having an HLB value of 4 to 10. - 特許庁