This ribozyme was obtained by designing a plurality of ribozymes which have the same ribozyme sequence which initiates the transcription by a tRNAval promotor which is a pol III promotor, examining parameters which determine the in vivo activity of a ribozyme, followed by selecting the ribozyme sequence considering its in vitro stability and posttranscriptional activity. 塩基配列(I): 5'-ACCGUUGGUUUCCGUAGUGUAGUGGUUAUCACGUUCGCCUAACACGCGAAAGGUCCCCGGUUCGAAACCGGGCACUACAAACACAACACUGAUGAGGACCGAAAGGUCCGAAACGGGCACGUCGGAAACGGUUUUU-3' 塩基配列(II): 5'-ACCGUUGGUUUCCGUAGUGUAGUGGUUAUCACGUUCGCCUAACACGCGAAAGGUCCCCGGUUCGAAACCGGGCACUACAAACCAACACACAACACUGAUGAGGACCGAAAGGUCCGAAACGGGCACGUCGGAAACGGUUUUU-3' - 特許庁