To provide an agent promoting the production of enzyme for nitrogen monooxide synthesis by finding out a substance which promotes enzymatic activity of cNOS for maintaining the production of NO at a proper level but inhibits promotion of enzymatic activity of iNOS and then utilizing the substance, and also provide a cosmetic or pharmaceutical composition each using the same substance. NOの産生量を適切なレベルにたもつために、cNOSの酵素活性を促進し、かつ、iNOSの酵素活性は促進しない物質を見出し、これを利用して優れた一酸化窒素合成酵素産生促進剤、延いては一酸化窒素産生促進化粧料組成物または医薬組成物を提供すること。 - 特許庁