To provide a promoter of information transfer between cells by GJ (gap junction) or expression of connexin43, or an external preparation for the skin for preventing and ameliorating aging of the skin. GJ(ギャップジャンクション)による細胞間情報伝達およびコネキシン43発現の促進剤または皮膚の老化予防改善皮膚外用剤の提供。 - 特許庁