出典:Wiktionary
出典:『Wiktionary』 (2024/09/03 21:59 UTC 版)
出典:Wikipedia
出典:『Wikipedia』 (2011/02/26 03:55 UTC 版)
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent excitotoxicity. Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. Many other drugs may cause convulsions as a side effect at high doses (e.g. bupropion, tramadol, pethidine, dextropropoxyphene) but only drugs whose primary action is to cause convulsions are known as convulsants.