出典:Wikipedia
出典:『Wikipedia』 (2011/07/01 08:44 UTC 版)
Ebrotidine is an H2 receptor antagonist with gastroprotective activity. It has a gastro-protective action against ethanol-, aspirin- or stress-induced gastric mucosal damage. The antisecretory properties of ebrotidine are similar to those of ranitidine, and approximately 10-fold greater than those of cimetidine. Ebrotidine has anti-Helicobacter pylori activity via inhibition of the urease enzyme and the proteolytic and mucolytic activities of the bacterium. However, its activity is synergistic with a number of antibacterial agents. Ebrotidine counteracts the inhibitory effects of H. pylori lipo-polysaccharides.