出典:Wiktionary
出典:『Wiktionary』 (2017/03/24 19:48 UTC 版)
meganuclease (複数形 meganucleases)
出典:Wikipedia
出典:『Wikipedia』 (2011/06/13 09:32 UTC 版)
Meganucleases are endodeoxyribonucleases characterized by a large recognition site (double-stranded DNA sequences of 12 to 40 base pairs); as a result this site generally occurs only once in any given genome. For example, the 18-base pair sequence recognized by the I-SceI meganuclease would on average require a genome twenty times the size of the human genome to be found once by chance. Meganucleases are therefore considered to be the most specific naturally occurring restriction enzymes.