英和和英

出典:『Wikipedia』 (2011/02/12 08:41 UTC 版)

英語による解説

引用

(–)-3β-(4-iodophenyl)tropane-2β-pyrrolidine carboxamide (RTI-229) is a potent and long-lasting stimulant drug which was developed in the 1990s as part of a large group of related analogues from the phenyltropane family. With the combination of two potent dopamine transporter (DAT) binding motifs attached to the tropane ring, the p-iodophenyl group at the 3β-position and a pyrrolidine carboxamide at 2β, RTI-229 has extremely high selectivity for the dopamine transporter (2600x and 4600x selective over NET and 5-HTT respectively) and is one of the most DAT-selective compounds in the RTI series.