AM-1235とは 意味・読み方・使い方

AM-1235 (1-(5-fluoropentyl)-3-(naphthalen-1-oyl)-6-nitroindole) is a drug which acts as a potent and reasonably selective agonist for the cannabinoid receptor CB1, with a Ki of 1.5nM at CB₁ compared to 20.4nM at CB2. While the 6-nitro substitution on the indole ring reduces affinity for both CB₁ and CB₂ relative to the unsubstituted parent compound AM-2201, CB₂ affinity is reduced much more, resulting in a CB₁ selectivity of around 13x. This is in contrast to other related compounds such as AM-1221 where a 6-nitro substitution instead confers significant selectivity for CB₂.