出典:Wiktionary
出典:『Wiktionary』 (2015/09/03 03:48 UTC 版)
aphidicolin (uncountable)
出典:Wikipedia
出典:『Wikipedia』 (2011/04/01 15:19 UTC 版)
Aphidicolin is defined as a tetracyclic diterpene antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses and an apoptosis inducer in HeLa cells.
Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.