出典:Wiktionary
出典:『Wiktionary』 (2025/01/08 00:49 UTC 版)
G-quadruplex (plural G-quadruplexes)
出典:Wikipedia
出典:『Wikipedia』 (2011/08/07 08:40 UTC 版)
Nucleic acid sequences which are rich in guanine are capable of forming four-stranded structures called G-quadruplexes (also known as G-tetrads or G4-DNA). These consist of a square arrangement of guanines (a tetrad), stabilized by Hoogsteen hydrogen bonding. They are further stabilized by the existence of a monovalent cation (especially potassium) in the center of the tetrads. They can be formed of DNA, RNA, LNA, and PNA, and may be intramolecular, bimolecular, or tetramolecular. Depending on the direction of the strands or parts of a strand that form the tetrads, structures may be described as parallel or antiparallel.