出典:Wikipedia
出典:『Wikipedia』 (2011/06/08 04:17 UTC 版)
Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as noradrenaline. Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.