英和和英

出典:『Wikipedia』 (2011/05/28 07:02 UTC 版)

英語による解説

引用

2-Iodoacetamide is an alkylating agent used for peptide mapping purposes. Its actions are similar to those of iodoacetate. It is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds. Also used in ubiquitin studies as an inhibitor of deubiquitinase enzymes (DUBs) because it alkylates the cysteine residues at the DUB active site. Like many other alkylating agents, iodoacetamide is highly toxic. In laboratory mice it has been shown to cause skin tumors and negatively affect reproductive ability. It may act as a human carcinogen, and may cause reproductive damage.