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出典:Wiktionary
出典:『Wiktionary』 (2025/08/01 23:49 UTC 版)
From the notion that specific genes have been knocked out of the genome.
knockout mouse (plural knockout mice)
出典:Wikipedia
出典:『Wikipedia』 (2011/06/29 19:39 UTC 版)
A knockout mouse is a genetically engineered mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.