出典:Wiktionary
出典:『Wiktionary』 (2025/09/09 15:26 UTC 版)
From aggre(gate) + -some.
aggresome (plural aggresomes)
出典:Wikipedia
出典:『Wikipedia』 (2010/08/05 08:49 UTC 版)
An aggresome is a proteinaceous inclusion body that forms when cellular degradation machinery is impaired or overwhelmed, leading to an accumulation of protein for disposal. The aggresomal response is believed to be a generalised-protective cell biological response to the presence of a high load of abnormal or damaged protein within the cytosol of a cell which fails to be eliminated by the usual ubiquitin proteasome system for protein degradation.