英和和英

別の表記

• triple negative

語源

First attested in 2004.

形容詞

triple-negative (not comparable)

1. (oncology) Of a breast cancer: characterized by the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
   • 2004 July 15, L. A. Carey, C. M. Perou, L. G. Dressler, et al., “Race and the poor prognosis basal breast tumor (BBT) phenotype in the population-based Carolina Breast Cancer Study (CBCS)”, Meeting Abstract: 2004 ASCO Annual Meeting, in Journal of Clinical Oncology, volume 22, number 14, →DOI, abstract number 9510:

     Multiple BrCa [breast cancer] microarray datasets (Sorlie et al PNAS 2003; van't Veer et al, Nature 2002; Sotiriou et al, PNAS 2003) suggest that 90% of BBT [basal breast tumor] are ER-negative, PR-negative, and HER-2 nonamplified (Perou C, unpublished). Thus, this “triple negative” phenotype may be used to identify and determine the frequency of BBT.

参考