出典:Wiktionary
anxiogenic (comparative more anxiogenic, superlative most anxiogenic)
出典:Wikipedia
出典:『Wikipedia』 (2011/08/11 00:23 UTC 版)
An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice. A number of agents are used to provoke anxiety (anxiogens) or panic (panicogens) in experimental models . Some of the most common substances are: sodium lactate, carbon dioxide (as carbogen), L-DOPA, caffeine, Modafinil, GABA antagonists such as DMCM, FG-7142 and ZK-93426, serotonergic agents such as mCPP and LY-293,284, adrenergic agents such as yohimbine, antipsychotics/dopamine antagonist such as ecopipam and reserpine, and cholecystokinin (CCK) (especially the tetrapeptide and octapeptide fragments CCK-4 and CCK-8). Studies have shown that 10 mL/kg of 0.5 molar sodium lactate infused intravenously over a 20-minute period will provoke a panic attack in most patients with panic disorder but not healthy control subjects.