出典:Wiktionary
出典:『Wiktionary』 (2009/07/25 23:56 UTC 版)
farnesyltransferase (countable かつ uncountable; 複数形 farnesyltransferases)
出典:Wikipedia
出典:『Wikipedia』 (2011/03/15 12:28 UTC 版)
Farnesyltransferase is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid called a farnesyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminus of a protein. Farnesyltransferase's targets include members of the Ras superfamily of small GTP-binding proteins critical to cell cycle progression. For this reason, several FTase inhibitors are undergoing testing as anti-cancer agents. FTase inhibitors have shown efficacy as anti-parasitic agents, as well. FTase is also believed to play an important role in development of progeria and various forms of cancers.