出典:Wiktionary
出典:『Wiktionary』 (2025/09/02 15:47 UTC 版)
From nal- (“opioid receptor antagonist/agonist”) + (hydr)ox(y) + -one.
naloxone (uncountable)
出典:Wikipedia
出典:『Wikipedia』 (2011/03/16 22:09 UTC 版)
(+)-Naloxone (Dextro-Naloxone) is a drug which is the "unnatural" enantiomer of the opioid antagonist drug (-)-naloxone. Unlike "normal" naloxone, (+)-naloxone has no significant affinity for opioid receptors, but instead has been discovered to act as a selective antagonist of Toll-like receptor 4. This receptor is involved in immune system responses, and activation of TLR4 induces glial activation and release of inflammatory mediators such as TNF-α and Interleukin-1.
出典:『Wikipedia』 (2011/07/29 18:46 UTC 版)
Naloxone is a an opioid antagonist drug developed by Sankyo in the 1960s. Naloxone is a drug used to counter the effects of opiate overdose, for example heroin or morphine overdose. Naloxone is specifically used to counteract life-threatening depression of the central nervous system and respiratory system. Naloxone is also experimentally used in the treatment for congenital insensitivity to pain with anhidrosis (CIPA), an extremely rare disorder (1 in 125 million) that renders one unable to feel pain. It is marketed under various trademarks including Narcan, Nalone, and Narcanti, and has sometimes been mistakenly called "naltrexate." It is not to be confused with naltrexone, an opioid receptor antagonist with qualitatively different effects, used for dependence treatment rather than emergency overdose treatment.