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出典:『Wikipedia』 (2011/05/01 14:09 UTC 版)

英語による解説

引用

RevCen is a family of non-coding RNA found in Schizosaccharomyces. It is a megastructure containing several siRNA which use the RNAi pathway to regulate heterochromatin formation. The long RNA transcript forms a secondary structure with several stem-loops which are processed by dicer into siRNA. This siRNA then initiate the formation of heterochromatin at the centromeres of fission yeast. Northern blot analysis confirmed the siRNAs were produced from the large RNA structure RevCen in vivo. As with all siRNAs, the enzyme dicer is responsible for dissecting dsRNA into the 21nt strech of double-stranded RNA. Human recombinant dicer enzyme processed the RevCen structure in vitro, though the same activity by yeast Dcr1 has not been confirmed.