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Wiktionary英語版
出典：Wiktionary
atacicept
出典:『Wiktionary』 (2011/09/06 10:49 UTC 版)
名詞
atacicept (uncountable)
- A recombinant fusion protein designed to inhibit B cells, thereby suppressing autoimmune disease.
- 2009 July 20, Andrew Pollack, “Trial for New Lupus Treatment Is Called Promising”, New York Times:
- Among the companies that have had setbacks or outright failures in clinical trials are Roche and Biogen Idec with their drug Rituxan; La Jolla Pharmaceutical with Riquent; Bristol-Myers Squibb with Orencia; ZymoGenetics and Merck Serono with atacicept; Genelabs Technologies with Prestara; Teva Pharmaceutical Industries with edratide; and Aspreva Pharmaceuticals and Roche with CellCept.
- 2009 July 20, Andrew Pollack, “Trial for New Lupus Treatment Is Called Promising”, New York Times:
ウィキペディア英語版
出典：Wikipedia
Atacicept
出典:『Wikipedia』 (2011/07/01 05:38 UTC 版)
英語による解説
ウィキペディア英語版からの引用
- 引用
Atacicept is a recombinant fusion protein designed to inhibit B cells, thereby suppressing autoimmune disease. The designer protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells, B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. Atacicept blocks activation of B cells by the tumor necrosis factor receptor superfamily member 13B (more commonly known as TACI), a transmembrane receptor protein found predominantly on the surface of B cells. Like the monoclonal antibody belimumab, atacicept blocks the binding of BLyS, but it also blocks APRIL. Binding of these TACI ligands induces proliferation, activation, and longevity of B cells and thus their production of autoantibodies. Atacicept is thought to selectively impair mature B cells and plasma cells with less impact on progenitor cells and memory B cells.
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- Wiktionary
- Text is available under Creative Commons Attribution-ShareAlike (CC-BY-SA) and/or GNU Free Documentation License (GFDL).
Weblio英和・和英辞典に掲載されている「Wiktionary英語版」の記事は、Wiktionaryのatacicept (改訂履歴)の記事を複製、再配布したものにあたり、Creative Commons Attribution-ShareAlike (CC-BY-SA)もしくはGNU Free Documentation Licenseというライセンスの下で提供されています。
- Wikipedia
- Text is available under Creative Commons Attribution-ShareAlike (CC-BY-SA) and/or GNU Free Documentation License (GFDL).
Weblio英和・和英辞典に掲載されている「Wikipedia英語版」の記事は、WikipediaのAtacicept (改訂履歴)の記事を複製、再配布したものにあたり、Creative Commons Attribution-ShareAlike (CC-BY-SA)もしくはGNU Free Documentation Licenseというライセンスの下で提供されています。
