英和和英

名詞

phosphodegron ‎(複数形 phosphodegrons)

1. A phosphorylated degron
   • 2015 October 27, “Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents”, in PLOS ONE^[1], DOI:10.1371/journal.pone.0140975:

     Activated Nek11 is capable of phosphorylating Cdc25A on sites within a phosphodegron that promotes recruitment of β-TrCP. This, in turn, leads to ubiquitin-mediated degradation of Cdc25A and cell cycle arrest [11 –13 ].