出典:Wikipedia
出典:『Wikipedia』 (2010/10/27 00:35 UTC 版)
Reverse tolerance or sensitization is the phenomenon of a reversal of the side-effects from a drug, or the reduction of insensitivity caused after drug tolerance has been established, or in some cases an additional increase of effects with continued use of a single drug existing alongside or not to a tolerance for other aspects of the same substance.. Typically this involves the use of an additional medication, or abstinence from a drug for a period of time, known as a drug holiday. Such drugs include amphetamines, or SSRIs. As a result, regular users commonly experience a quick decrease of unwanted side effects, without an equivalent loss of its stimulant properties. Notably, the sensitization is induced more quickly, and persists far longer than withdrawal-related effects, suggesting a phenomenon more complex than a simple tolerance-induced withdrawal syndrome..