英和和英

出典:『Wikipedia』 (2011/06/07 11:17 UTC 版)

英語による解説

引用

Tiling Arrays are a subtype of microarray chips. They function on a similar principle to traditional microarrays in that labeled target molecules are hybridized to unlabeled probes fixed on to a solid surface. Tiling arrays differ in the nature of the probes. Short fragments are designed to cover the entire genome or contiguous regions of the genome. Depending on the probe lengths and spacing different degrees of resolution can be achieved. Number of features on a single array can range from 10,000 to greater than 6,000,000, with each feature containing millions of copies of one probe. Traditional DNA microarrays designed to look at gene expression use a few probes for each known or predicted gene. In contrast, tiling arrays can produce an unbiased look at gene expression because previously unidentified genes can still be incorporated. On top of individual gene expression analysis, other uses of tiling arrays are in transcriptome mapping, ChIP-chip, MeDIP-chip and DNase Chip studies and array CGH among others. Tiling arrays are quickly becoming one of the most powerful tools in genome-wide investigations.