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出典:『Wikipedia』 (2011/01/13 19:22 UTC 版)

英語による解説

引用

UH-232 ((+)-UH232) is a drug which acts as a subtype selective mixed agonist-antagonist for dopamine receptors, acting as a weak partial agonist at the D3 subtype, and an antagonist at D₂Sh autoreceptors on dopaminergic nerve terminals. This causes dopamine release in the brain and has a stimulant effect, as well as blocking the behavioural effects of cocaine. It was trialled for the treatment of schizophrenia but unexpectedly caused symptoms to become worse.