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出典:『Wikipedia』 (2011/04/11 18:14 UTC 版)

英語による解説

引用

Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity. as well as its effect on cardiac vagal drive Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe.