myddosomeとは 意味・読み方・使い方

名詞

myddosome (複数形 myddosomes)

1. A complex of signalling proteins that has a role in the immune response
   • 2016 January 12, “Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice”, in PLOS ONE‎^[1], DOI:10.1371/journal.pone.0146326:

     This signaling complex, the so-called myddosome, assembles in a hierarchical manner so that IRAKs can associate with tumor necrosis factor receptor-associated factor 6 (TRAF6), which, via a complex signaling cascade, ultimately enables NF-κB to translocate into the nucleus where it regulates gene transcription.