出典:Wiktionary
出典:『Wiktionary』 (2017/01/11 20:39 UTC 版)
chromodomain (複数形 chromodomains)
出典:Wikipedia
出典:『Wikipedia』 (2011/07/01 07:37 UTC 版)
A chromodomain (chromatin organization modifier ) is a protein structural domain of about 40-50 amino acid residues commonly found in proteins associated with the remodeling and manipulation of chromatin. The domain is highly conserved among both plants and animals, and is represented in a large number of different proteins in many genomes, such as that of the mouse. Some chromodomain-containing genes have multiple alternative splicing isoforms that omit the chromodomain entirely. In mammals, chromodomain-containing proteins are responsible for aspects of gene regulation related to chromatin remodeling and formation of heterochromatin regions. Chromodomain-containing proteins also bind methylated histones and appear in the RNA-induced transcriptional silencing complex.