英和和英

出典:『Wikipedia』 (2011/06/22 06:32 UTC 版)

英語による解説

引用

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with K_i values of 0.46nM at CB₁ and 0.69nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB₁ K_i 0.69 nM) and JWH-182 (CB₁ K_i 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB₁ K_i 1.2 nM). It was discovered by and named after Dr. John W. Huffman. JWH-210 and JWH-122 were banned in Sweden on 1st October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products.