英和和英

名詞

prontosil (uncountable)

1. (pharmacology) The antibacterial drug 4-[(2,4-diaminophenyl)azo]benzenesulfonamide.
   • 1951 July, Richard D. Reekie, “Critical Analysis of Recent Advances in Gynecology”, in Northwest Medicine, volume 50, number 7, Portland, Ore.: Northwest Medical Publishing Association, page 508:

     In the field of therapeutic aids, chemotherapy and antibiotics have been completely developed since that time. We had prontosil and neoprontosil and thought we were very fortunate.

   • 2015 July 25, Mengxiao Gu et al., “Response of a clinical Escherichia coli strain to repeated cefquinome exposure in a piglet tissue-cage model”, in BMC Veterinary Research‎^[1], volume 11, →DOI:

     Since 1935 when Domagk demonstrated that prontosil provided effective therapy in a murine pneumococcal infection model, the use of animal infection models has become an integral part of the evaluation of new antimicrobial agents and new therapeutic approaches for clinical trials in humans.