rat | 遺伝子名 | CD59 antigen |
同義語(エイリアス) | MACIF; Cd59a; Membrane attack complex inhibition factor; MAC-inhibitory protein; Protectin; MAC-IP; Cd59; CD59 glycoprotein precursor | |
SWISS-PROTのID | SWISS-PROT:P27274 | |
EntrezGeneのID | EntrezGene:25407 | |
その他のDBのID | RGD:2311 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2011/03/21 14:40 UTC 版)
CD59 antigen (also called 1F-5Ag, H19, HRF20, MACIF, MIRL, P-18 or protectin) inhibits formation of membrane attack complex (MAC), thus protecting cells from complement-mediated lysis. It has a signaling role, as a GPI anchored molecule, in T cell activation and appears to have some role in cell adhesion through CD2 (controversial). CD59 associates with C9, inhibiting incorporation into C5b-8 preventing terminal steps in polymerization of the (MAC) in plasma membranes. Genetic defects in GPI-anchor attachment that cause a reduction or loss of both CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal nocturnal hemoglobinuria (PNH).