英和和英

出典:『Wikipedia』 (2011/04/02 13:20 UTC 版)

英語による解説

引用

Eph receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an Eph receptor interacts with ephrin ligands, which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Some Eph receptors such as EPHB4 participate in both forward and reverse signalling pathways, by either transducing a signal through their own kinase domain, or by initiating a signalling cascade through certain ephrin ligands.