a drug used to treat certain types of breast cancer in women and men. it is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. tamoxifen is also being studied in the treatment of other types of cancer. it blocks the effects of the hormone estrogen in the breast. tamoxifen is a type of antiestrogen. also called tamoxifen citrate.
出典:Wikipedia
出典:『Wikipedia』 (2011/07/19 20:24 UTC 版)
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist. It has been the standard endocrine (anti-estrogen) therapy for hormone receptor-positive early breast cancer in pre-menopausal women, although aromatase inhibitors have been proposed.
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