To provide a cancer gene vaccine capable of producing a fused protein of a cancer antigen with ubiquitin in a cytoplasm by ligating a gene encoding ubiquitin which is a Tag(inducing) gene toward proteasome to a cancer antigen gene and directly transferring the gene thus ligated into cytoplasm by the use of a gene gun and capable of inducing a potent anticancer tumor immunity mainly owing to cancer antigen-specific CD8^+ killer T cells by using this procedure. プロテアソームへ導くTag(誘導)分子であるユビキチンをコードする遺伝子を癌抗原遺伝子と結合させ、遺伝子銃で細胞質内に直接その結合遺伝子を導入することにより、細胞質内で癌抗原とユビキチンの融合蛋白質を産生させることができ、この操作により癌抗原に特異的なCD8^+キラーT細胞を主体とした強力な抗癌腫瘍免疫を誘導させることが可能な癌遺伝子ワクチンを提供する。 - 特許庁
1. The title constituting the patent of invention shall contain: (a) the indication of the title of the invention; (b) the name of the owner or owners, and, where applicable, their representative; (c) the name of the inventor or inventors, unless the inventor or inventors opposes the disclosure of their identity; (d) the indication of the date of filing, the date of publication, and the date of the grant of the patent; (e) where applicable, a mention of the rights of priority; (f) where applicable, the data relating to the immunity deriving from the exhibition; (g) the indication of the international classes. (1) 発明特許証には,次の事項を含まなければならない。(a) 発明の名称の表示 (b) 1人又は2人以上の特許権者の名称,及び該当する場合は,それらの者の代理人の名称 (c) 1人又は2人以上の発明者がそれらの者の身元の開示に反対しない限り,発明者の名称 (d) 出願日,公告日,及び特許付与日の表示 (e) 該当する場合は,優先権の記載 (f) 該当する場合は,博覧会から生じた免除特権に関する資料 (g) 国際分類の表示 - 特許庁
In the mid Heian period, kaihatsu ryoshu (local nobles who actually developed the land) began to donate their land to temples or high-ranking aristocrats in order to make their land fuyusoden (donated-type of shoen [manor]); however, they were required to submit kugen (official documents authorized by kokushi [provincial governor] or Gunji [local magistrate] for transfer of the ownership of private property) consisting of daijokanpu (official document issued by Daijokan, Grand Council of State) and minbushofu (official document issued by the minister of minbusho) based on the chokkyo (the imperial sanction) to have their land designated as fuyusoden -- Shoen which consisted of fuyusoden with the complete set of documents submitted was called Kanshofu sho (a shoen enjoying immunity from taxation by virtue of having official documents from both the Council of State and the Ministry of Popular Affairs), and shoen which was virtually treated as fuyusoden merely with approval of kokushi was called kokumen shoen (provincially exempted shoen).
平安時代中期になると、開発領主が自らの土地をこの不輸租田にするために寺社や上級貴族に寄進するようになる(寄進地系荘園)が、不輸租田の指定には勅許とそれに基づく太政官符及び民部省符からなる公験が必要とされており、それらが揃った不輸租田によって構成された荘園を官省符荘、単に国司が承認したために事実上の不輸租田の対象となっていたものを国免荘田と呼ばれた。 - Wikipedia日英京都関連文書対訳コーパス