a protein made from a fusion gene, which is created by joining parts of two different genes. fusion genes may occur naturally in the body by transfer of dna between chromosomes. for example, the bcr-abl gene found in some types of leukemia is a fusion gene that makes the bcr-abl fusion protein. fusion genes and proteins can also be made in the laboratory by combining genes or parts of genes from the same or different organisms.
出典:Wiktionary
fusion protein (複数形 fusion proteins)
出典:Wikipedia
出典:『Wikipedia』 (2010/12/27 15:33 UTC 版)
Fusion proteins or chimeric proteins are proteins created through the joining of two or more genes which originally coded for separate proteins. Translation of this fusion gene results in a single polypeptide with functional properties derived from each of the original proteins. Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics. Chimeric mutant proteins occur naturally when a complex mutation, such as a chromosomal translocation, tandem duplication, or retrotransposition creates a novel coding sequence containing parts of the coding sequences from two different genes. Naturally occurring fusion proteins are commonly found in cancer cells, where they may function as oncoproteins. The bcr-abl fusion protein is a well-known example of an oncogenic fusion protein, and is considered to be the primary oncogenic driver of chronic myelogenous leukemia.