出典:Wiktionary
Shortened from just another kinase (being part of a large number of discoveries at the time); see Janus.
出典:Wikipedia
出典:『Wikipedia』 (2011/06/21 06:51 UTC 版)
Janus kinase (JAK, or "Just another kinase") is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named "just another kinase" 1 & 2 (since they were just two of a large number of discoveries in a PCR-based screen of kinases), but were ultimately published as "Janus kinase". The name is taken from the two-faced Roman god of doorways, Janus, because the JAKs possess two near-identical phosphate-transferring domains. One domain exhibits the kinase activity while the other negatively regulates the kinase activity of the first.