a synthetic form of the hormone estrogen that was prescribed to pregnant women between about 1940 and 1971 because it was thought to prevent miscarriages. diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it. it also has been linked to an increased risk of clear cell carcinoma of the vagina or cervix in daughters exposed to diethylstilbestrol before birth. also called des.
出典:Wikipedia
出典:『Wikipedia』 (2011/05/23 06:08 UTC 版)
Diethylstilbestrol (DES, spelled diethylstilboestrol in British English) is a synthetic nonsteroidal estrogen that was first synthesized in 1938. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1970, DES was given to pregnant women under the mistaken belief it would reduce the risk of pregnancy complications and losses. In 1971, DES was shown to cause a rare vaginal tumor in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew DES from use in pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complication during the lifetime of those exposed. The United States National Cancer Institute recommends that women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the drug. Women exposed to DES are commonly referred to as "DES daughters".