CITRULLINATEDとは 意味・読み方・使い方

形容詞

citrullinated (comparative more citrullinated, superlative most citrullinated)

1. (biochemistry) Reacted with, or converted to, citrulline.
   • 2019, Geeta Rai, NETosis: Immunity, Pathogenesis and Therapeutics, Elsevier (Academic Press), page 106:

     Initially it has been suggested that fibrin is the most citrullinated protein in RA joints (Iobagiu et al., 2011), but now the presence of citrullinated vimentin and aggrecan is also detected (Glant et al., 2016).

   • 2019, Venkatesh V. Nemmara, Paul R. Thompson, Development of Activity-Based Proteomic Probes for Protein Citrullination, Benjamin F. Cravatt, Ku-Lung Hsu, Eranthie Weerapana (editors), Activity-Based Protein Profiling, Springer, page 244,

     Given that aberrant citrullination is a hallmark of various autoimmune diseases and certain tumor types, it is important to develop protein detection methods to identify citrullinated proteins in complex biological systems.

   • 2020, Wolfgang Faigle et al., “Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis”, in Paulus Stefan Rommer, Martin S. Weber, Zsolt Illes, Uwe K. Zettl, editors, Multiple Sclerosis - From Bench to Bedside, Frontiers Media, page 40:

     It had already been described in AD (25) and is one of the most citrullinated proteins besides MBP and GFAP in WMMS.