DNA strand breakとは 意味・読み方・使い方

To provide a recombinant cell obtained by a method for site-specifically inducing at least one break of a double strand to a chromosome DNA.例文帳に追加

染色体ＤＮＡに部位特異的に、二本鎖の切れ目を少なくとも一つ誘導する方法により得られる組換え細胞の提供。 - 特許庁

To provide a method and procedure relating to a treatment of cancers deficient in homologous recombination (HR) dependent DNA double strand break (DSB) repair.例文帳に追加

相同組換え(ＨＲ)依存的ＤＮＡ二本鎖切断(ＤＳＢ)修復を欠損する癌の治療に関する方法及び手段の提供。 - 特許庁

The agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break is used for treatment of lung cancer, colon cancer, pancreatic cancer, stomach cancer, ovary cancer, cervical cancer, breast cancer and prostate cancer, particularly, of breast cancer.例文帳に追加

肺癌、大腸癌、膵臓癌、胃癌、卵巣癌、子宮頸癌、乳癌及び前立腺癌、特に乳癌の治療における、DNA鎖切断（又は切断部）の修復を仲介する酵素の活性を阻害する薬剤。 - 特許庁

The invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.例文帳に追加

相同的組換えを仲介する遺伝の欠陥によって引き起こされる疾患を治療するための医薬製造における、DNA鎖切断の修復を仲介する酵素の活性を阻害する薬剤。 - 特許庁

Inhibition of base excision repair (BER) pathway using inhibitors targeting base excision repair components, such as PARP is selectively lethal to cells deficient in HR dependent DNA double-strand break (DSB) repair.例文帳に追加

塩基除去修復の成分（ＰＡＲＰなど）を標的とする阻害剤を用いた塩基除去修復(ＢＥＲ)経路の阻害が、ＨＲ依存的ＤＮＡ二本鎖切断(ＤＳＢ)修復を欠損する細胞に選択的に致死性がある。 - 特許庁