ＤＮＡ鎖切断の英語

The agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break is used for treatment of lung cancer, colon cancer, pancreatic cancer, stomach cancer, ovary cancer, cervical cancer, breast cancer and prostate cancer, particularly, of breast cancer.例文帳に追加

肺癌、大腸癌、膵臓癌、胃癌、卵巣癌、子宮頸癌、乳癌及び前立腺癌、特に乳癌の治療における、DNA鎖切断（又は切断部）の修復を仲介する酵素の活性を阻害する薬剤。 - 特許庁

The invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.例文帳に追加

相同的組換えを仲介する遺伝の欠陥によって引き起こされる疾患を治療するための医薬製造における、DNA鎖切断の修復を仲介する酵素の活性を阻害する薬剤。 - 特許庁

To provide a method for the quantitative determination of the amount of phosphoric acid residues at the 3'-terminal of the cleaved part of a DNA strand caused by ionizing radiation, etc., the amount of the 3'-terminal of total cleaved part of the strand, and the amount of damaged bases.例文帳に追加

電離放射線等によって生じるDNA鎖切断部の3'側末端のリン酸残基量、全体の鎖切断部の3'末端の量、および損傷塩基の量を、定量化する方法の提供。 - 特許庁

The amount of phosphoric acid residues at the 3'-terminal of the cleaved part of a DNA strand, the amount of the 3'-terminal of total cleaved part of the strand and the amount of damaged bases are quantitatively determined by clarifying the production rate of 5'-monodeoxynucleotide (pdN) from the cleaved strand terminal by using a phosphodiesterase which is a 3'→5' exonuclease.例文帳に追加

3'→5'エキソヌクレアーゼであるホスホジエステラーゼにより、5'-モノデオキシヌクレオチド（pdN）が鎖切断末端から生成される速度を明らかにすることにより、DNA鎖切断部の3'側末端のリン酸残基量、全体の鎖切断部の3'末端の量、および損傷塩基の量を、定量化する。 - 特許庁