| human | 遺伝子名 | ACVR2B |
| 同義語(エイリアス) | MGC116908; activin A receptor, type IIB; Activin receptor type IIB; Activin receptor type 2B precursor; ACTR-IIB; ActR-IIB | |
| SWISS-PROTのID | SWISS-PROT:Q13705 | |
| EntrezGeneのID | EntrezGene:93 | |
| その他のDBのID | HGNC:174 |
| mouse | 遺伝子名 | Acvr2b |
| 同義語(エイリアス) | MGC118477; Activin receptor type IIB; Activin receptor type 2B precursor; ActRIIB; activin receptor IIB; ACTR-IIB | |
| SWISS-PROTのID | SWISS-PROT:P27040 | |
| EntrezGeneのID | EntrezGene:11481 | |
| その他のDBのID | MGI:87912 |
| rat | 遺伝子名 | Acvr2b |
| 同義語(エイリアス) | Actriib; ActRIIB type II activin receptor B; Activin receptor type 2B precursor; Activin receptor type IIB; Activine receptor 2b (transmembrane serine kinase); activin receptor IIB; ACTR-IIB | |
| SWISS-PROTのID | SWISS-PROT:P38445 | |
| EntrezGeneのID | EntrezGene:25366 | |
| その他のDBのID | RGD:2028 |
| zfish | 遺伝子名 | acvr2b |
| 同義語(エイリアス) | fj97d11; activin receptor IIb; actrIIb; wu:fj97d11; actr2b | |
| SWISS-PROTのID | --- | |
| EntrezGeneのID | EntrezGene:30457 | |
| その他のDBのID | ZFIN:ZDB-GENE-980526-549 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2011/02/07 16:21 UTC 版)
Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.