出典:Wiktionary
出典:Wikipedia
出典:『Wikipedia』 (2011/07/02 03:15 UTC 版)
HOTAIR (for HOX antisense intergenic RNA) is a gene at 12q13.13 size 6,232 bp encoding 2.2 kbp long noncoding RNA molecule, which controls gene expression on chromosome 2. Its source DNA is located within a HOXC gene cluster. It is the first example of an RNA expressed on one chromosome influencing transcription on another chromosome. It is shuttled from chromosome 12 to chromosome 2 by the Suz-Twelve protein. The 5' end of HOTAIR interacts with a Polycomb-group protein Polycomb Repressive Complex 2 (PRC2) and as a result regulates chromatin state. It is required for gene-silencing of the HOXD locus by PRC2. The 3' end of HOTAIR interacts with the histone demethylase LSD1.
hot air
hot air
ジメジメした空気
of electrical science, the arc heat