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出典:『Wikipedia』 (2011/05/21 04:37 UTC 版)

英語による解説

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Lamotrigine, marketed as Lamictal (pronounced /ləˈmɪktəl/) by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy, it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, Lamotrigine also seems to act as an effective mood stabilizer, and in fact has been the only U.S. Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants (due to lamotrigine's being a Phenyltriazine), lamotrigine has relatively few side-effects and does not require blood monitoring in monotherapy. The exact way lamotrigine works is unknown. Some think that it is a sodium channel blocker, though it is interesting to note that lamotrigine shares very few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, (e.g., Oxcarbazepine), which may suggest that lamotrigine has a different mechanism of action. Lamotrigine is inactivated by hepatic glucuronidation.