minimal doseとは 意味・読み方・使い方

Case1 is the case approaching the Minimal Anticipated Biological Effect Level (MABEL) and Case2 differs from the conventional use of the No Observed Adverse Effect Level (NOAEL). When calculating the first-in-human dose, the majority of cases will fall into the following categories: cases in which the dose per unit body weight will be obtained from the MABEL or NOAEL (mg/kg) and will then be divided by a safety factor; cases in which the dose (mg/m2) per unit body surface area (m2) will be used for conversion to the Human Equivalent Dose (HED) to ensure equivalence between study animals and human subjects.例文帳に追加

事例１は NOAELを設定根拠した事例，事例２は MABEL を設定根拠にした事例を示しますが，これらの事例のように体重あたりの投与量として得られた MABELまたは NOAEL（mg/kg）の他 - 厚生労働省

To provide a method for intracellular transduction with which the dose of a transgenic peptide can be suppressed to a minimal dose and effects of the transgenic peptide can further be exhibited to a maximum so that not only cancer cell growth can be inhibited but also various functional molecular target effects can remarkably be raised and to provide a kit for realizing the method.例文帳に追加

導入ペプチドの投与量をできるかぎり低用量に抑え、さらに導入ペプチドの効果を最大限発揮でき、がん細胞増殖抑制のみならず多種多様の機能的分子標的効果を飛躍的に上げる細胞導入方法及びそれを実現するためのキットの提供。 - 特許庁