| fly | 遺伝子名 | AP180 |
| 同義語(エイリアス) | saisoog; dAP-3; BcDNA:GM10787; Like-AP180; sig; lap; complementation group 12; lap/AP180; CG2520; like-AP180; l(3)neo34 | |
| SWISS-PROTのID | SWISS-PROT:Q9VI75 | |
| EntrezGeneのID | EntrezGene:40863 | |
| その他のDBのID | FlyBase:FBgn0026210 |
| human | 遺伝子名 | AP180 |
| 同義語(エイリアス) | Clathrin coat-associated protein AP180; SNAP91; KIAA0656; 91 kDa synaptosomal-associated protein; DKFZp781O0519; Clathrin coat assembly protein AP180 | |
| SWISS-PROTのID | SWISS-PROT:O60641 | |
| EntrezGeneのID | EntrezGene:9892 | |
| その他のDBのID | HGNC:14986 |
| mouse | 遺伝子名 | AP180 |
| 同義語(エイリアス) | Clathrin coat-associated protein AP180; Snap91; F1-20; Clathrin coat assembly protein AP180; Phosphoprotein F1-20; mKIAA0656; 91kDa; 91 kDa synaptosomal-associated protein; synaptosomal-associated protein 91 | |
| SWISS-PROTのID | SWISS-PROT:Q61548 | |
| EntrezGeneのID | EntrezGene:20616 | |
| その他のDBのID | MGI:109132 |
| rat | 遺伝子名 | Ap180 |
| 同義語(エイリアス) | Clathrin coat-associated protein AP180; Snap91; synaptosomal-associated protein 91 kDa; 91 kDa synaptosomal-associated protein; Clathrin coat assembly protein AP180; assembly protein 180 (AP180) | |
| SWISS-PROTのID | SWISS-PROT:Q05140 | |
| EntrezGeneのID | EntrezGene:65178 | |
| その他のDBのID | RGD:69276 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2010/05/30 23:48 UTC 版)
AP180 is a protein that plays an important role in clathrin-mediated endocytosis of synaptic vesicles. It is capable of simultaneously binding both membrane lipids (via an ANTH domain) and clathrin and is therefore thought to recruit clathrin to the membrane of newly invaginating vesicles. In Drosophila melanogaster (fruit flies), deletion of the AP180 homologue, leads to enlarged but much fewer vesicles and an overall decrease in transmitter release. In D. melanogaster it was also shown that AP180 is also required for either recycling vesicle proteins and/or maintaining the distribution of both vesicle and synaptic proteins in the nerve terminal. A ubiquitous form of the protein in mammals, CALM, (Clathrin-assembly lymphoid myeloid leukaemia protein) is named after its association with myeloid and lymphoid leukemias where some translocations map to this gene. The C-terminus of AP180 is a powerful and specific inhibitor of clathrin-mediated endocytosis.