| human | 遺伝子名 | Galectin-3 |
| 同義語(エイリアス) | IgE-binding protein; L-31; Galactoside-binding protein; GAL3; Mac-2 antigen; LGALS3; 35 kDa lectin; MAC2; Galactose-specific lectin 3; Lectin L-29; Carbohydrate-binding protein 35; LGALS2; MAC-2; CBP35; CBP 35; soluble; Laminin-binding protein; GALIG; galactoside-binding; GALBP | |
| SWISS-PROTのID | SWISS-PROT:P17931 | |
| EntrezGeneのID | EntrezGene:3958 | |
| その他のDBのID | HGNC:6563 |
| mouse | 遺伝子名 | galectin-3 |
| 同義語(エイリアス) | lectin, galactose binding, soluble 3; IgE-binding protein; CBP 35; Laminin-binding protein; Mac-2 antigen; L-34; Galectin-3; 35 kDa lectin; GBP; Mac-2; Galactose-specific lectin 3; L-34 galactoside-binding lectin; Lectin L-29; Carbohydrate-binding protein 35; gal3; Lgals3 | |
| SWISS-PROTのID | SWISS-PROT:P16110 | |
| EntrezGeneのID | EntrezGene:16854 | |
| その他のDBのID | MGI:96778 |
| rat | 遺伝子名 | Galectin-3 |
| 同義語(エイリアス) | IgE-binding protein; lectin, galactose binding, soluble 3; CBP 35; Laminin-binding protein; Mac-2 antigen; MGC105387; 35 kDa lectin; Galactose-specific lectin 3; gal-3; Lectin L-29; Carbohydrate-binding protein 35; Lgals3; IgE binding protein | |
| SWISS-PROTのID | SWISS-PROT:P08699 | |
| EntrezGeneのID | EntrezGene:83781 | |
| その他のDBのID | RGD:69356 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2011/03/04 23:21 UTC 版)
Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides. Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22. It is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space. This protein has been shown to be involved in the following biological processes: cell adhesion, cell activation and chemoattraction, cell growth and differentiation, cell cycle, and apoptosis. Given galectin-3’s broad biological functionality, it has been demonstrated to be involved in cancer, inflammation and fibrosis, heart disease, and stroke. Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and Ventricular remodeling. Elevated levels of galectin-3 have been found to be significantly associated with higher risk of death in both acute decompensated heart failure and chronic heart failure populations.