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それが問題?
それが問題?
問題でも?
Is there a problem?
これって、問題あり?
Is there a problem?
Have you experienced any problems with ~ so far?
Have you experienced any difficulties with ~?
You look confused.
How do you feel about that problem?
Do you have any trouble with that?
Is there a problem?
Is there a problem?
難問.
Would it be acceptable for me to ~ ?
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